"Avengers: Endgame" is three hours and one minute long, which makes one nervous about taking bathroom breaks at the worst possible time. So we did that for you (with as few spoilers as possible):
—If need be, the first 17 minutes of the film can be missed (rehashing of Thanos' handiwork from the previous film) before the film's title being revealed.
—As soon as the posse mentions getting the team together (around the hour and 5 minute mark), feel free to make a run for it. And remember, the team has to be gathered from around the globe, so you have about a solid 12 minutes.
—While a moment between Rocket and Thor is motivational, if nature calls, feel free to answer. (That's about an hour and 35 minutes in).
—As for the last hour? Stick it out. Happy endings, less than happy ones and so many feels happen.
Dr. Stephanie Kielb, associate professor of Urology, Medical Education and Obstetrics and Gynecology at Northwestern University's Feinberg School of Medicine said pace yourself, stay hydrated and there's no such thing as "breaking the seal."
"People say that a lot when drinking alcohol, but that's not a physiological effect — it's not like once you pee, you have to pee more," she said. "Empty your bladder before the movie starts. A short time holding your bladder once or twice is not a big deal, it's not harmful. If you drink a giant Diet Coke right before going into the movie or during the movie, that's going to make your bladder fill up faster. Caffeine is also a bladder irritant, so it's also going to make you need to go. That might not be the best of ideas."